The lesions have been described as hamartomatous malformations of the pilosebaceous duct junction hair follicle unit. Steatocystoma multiplex, he 40x 3623 steatocystoma. These growths begin in the skins sebaceous glands, which normally produce an oily substance called sebum that lubricates the skin and hair. Steatocystoma simplex, an entity not previously described, to my knowledge, occurred in 16 women and 14 men. Steatocystoma multiplex of the breast dr ayush goel and radswiki et al. Steatocystoma multiplex is an autosomal dominant condition that presents with multiple lesions, but is otherwise identical in appearance and histology to steatocystoma simplex 2. Steatocystoma, he 10x 1695 steatocystoma, he 20x 1900. Steatocystoma simplex, the nonheritable solitary counterpart of steatocystoma multiplex sm, was first described as a distinct entity by brownstein in 1982. A 56yearold man of wapishana ethnicity presented with complaints of referred penile discomfort and pain during sexual. The majority of cases are seen in the second and third decade of life, however cases can present at birth 5 and as old as 78 years. Pdf a case of steatocystoma simplex involving the scalp.
Cysts are hollow lumps, and sebum is an oily substance produced by the sebaceous glands that are found near hair roots. At the first examination, a yellowish, relatively smooth surface mass was observed in the right lacrimal caruncle. The clinical, histological and immunohistochemical. Clinical misdiagnosis of steatocystoma simplex of eyebrow in a. The tissue undergoes a series of steps before it reaches the examiners desk to be thoroughly examined microscopically to arrive at a particular diagnosis. It is usually characterised by multiple, asymptomatic, skincoloured or yellowish, sebumcontaining dermal cysts.
Cysts most often develop on the chest, upper arms and face, but may develop all over the body in some cases. Mar 28, 2020 steatocystoma multiplex is a rare condition in which many small cysts filled with sebum appear on the skin. Eleven cysts were situated on the face, six on the limbs, and five on the chest. Jan, 2017 the clinical, histological and immunohistochemical characteristics and nomenclature of meibomian gland ductal cysts intratarsal keratinous cysts and eyelid steatocystomas. Steatocystoma multiplex an uncommon lesion with special. Some of the frequent locations of sm include neck, chest. Department of pathology, subharti medical college, nh58, delhi haridwar bypass, meerut, uttar pradesh, india. A case of steatocystoma simplex involving the scalp. Steatocystoma multiplex university of miamis research profiles. It is important in making a differential diagnosis to establish age of onset, location, appearance of lesions, and mode of inheritance. This is the third reported case of a steatocystoma simplex in the lacrimal caruncle.
Steatocystoma simplex and multiplex symptoms and pictures. Steatocystoma multiplex genetics home reference nih. Elementary, sebaceous, solo steatocystoma simplex juniper. Steatocystoma simplex is a noninheritable solitary counterpart of a steatocystoma multiplex 16. If a single cyst of this type is found, it is called steatocystoma simplex. Pdf steatocystoma is a benign adnexal tumor originating from the pilosebaceous.
Jan 31, 2018 steatocystoma is a benign noncancerous skin cyst that arises from a sebaceous gland 1,2. Steatocystoma multiplex an overview sciencedirect topics. Steatocystoma simplex is characterized by solitary, nonheritable growth mostly seen on face while multiplex is commonly seen on the axillae, groin, trunk and proximal extremities. Steatocystoma multiplex of the breast radiology reference. Steatocystoma simplex is a skin condition characterized by a skin lesion that occurs with equal frequency in adult women and men, and is typically found on the face, trunk, or extremities. Steatocystoma simplex was initially scripted as a definitive entity and an extremely. Steatocystoma simplex differs from steatocystoma multiplex in being a solitary cystic nodule with no family history that is comparatively rare. C, photomicrograph of surgical specimen shows cystic space lined with. The steatocystoma simplex is a cutaneous tumor thought to be a circumscribed malformation arising from the pilosebaceous duct junction. Gordon spratt, ea kaplan, j patel, rr kamino, h ramachandran, sm. The clinical diagnosis was usually some type of cyst. The steatocystoma simplex is a cutaneous tumor thought to be a. A 60yearold male presented with a history of a slowly progressing mass in the right lacrimal caruncle since several years before his initial visit. The histopathologic examination revealed a thinwalled cyst consisting of.
Steatocystoma simplex refers to a presence of a single cyst, which is usually acquired, and steatocystoma multiplex refers to a condition with multiple cysts, which is usually hereditary 1. Steatocystoma multiplex, is a benign, autosomal dominant congenital condition resulting in multiple cysts on a persons body. Sep 27, 2011 mutation in kereatin 17 is also associated with pachyonychia congenita type 2. Steatocystoma multiplex is a rare inherited disorder in which numerous cysts develop at puberty. Steatocystoma multiplex cause, treatment and diet for. It can be sporadic, familial or a part of a syndrome. Steatocystoma multiplex and adolescent development. Steatocystoma presents as a solitary lesion steatocystoma simplex or multiple lesions steatocystoma multiplex in adolescents or young adults. The histologic, enzyme histochemical, and ultrastructural findings were those of steatocystoma multiplex.
It is rarely seen on face and scalp and is inherited, so is termed steatocystoma multiplex congenita. Chapter 1 introducton histopathology definition it is a branch of pathology which deals with the study of disease in a tissue section. Tirakunwichacha s, vaivanijkul j 2009 steatocystoma simplex of the eyelid. The condition can be caused by mutations in the krt17 gene. Steatocystoma simplex is an uncommon skin lesion with a histological pattern that is identical to that of steatocystoma multiplex. Steatocystoma multiplex is a skin disorder characterized by the development of multiple noncancerous benign cysts known as steatocystomas.
Cutaneous keratocysts also have a histopathological resemblance to steatocystoma by a festooned lining con tinuous with a thick stratified squamous wall that. We describe a case of a steatocystoma simplex in the lacrimal caruncle. Steatocystoma simplex is characterized by solitary cystic nodules with no family history and is a rare benign cutaneous cyst arising from the pilosebaceous duct junction. Steatocystoma multiplex is an uncommon benign disorder typically manifests as multiple asymptomatic intradermal cysts. As the lacrimal caruncle contains elements of both conjunctiva and skin 15, steatocystomas may have developed from the lacrimal caruncle, in a similar manner as other skin regions. Histologically, it appears as an epitheliumlined cystic wall associated with sebaceous lobules. The cysts may become inflamed and cause scarring when they heal. Steatocystoma multiplex is a rare benign disorder of the pilosebaceous unit.
The solitary cysts are identi cal to those of the typical syndrome. Steatocystoma multiplex involving the face and scalp. In contrast, steatocystoma simplex in the periocular region is extremely rare 4, 5, with only. Steatocystoma simplex is the nonhereditary counterpart to the hereditary steatocystoma multiplex, clinically both are almost identical. Only two single case reports of a steatocystoma simplex in the lacrimal caruncle have been reported 2, 3. Steatocystoma simplex is the solitary counterpart to steatocystoma multiplex. Usually presents as multiple cysts steatocystoma multiplex, less commonly as solitary cyst steatocystoma simplex in adulthood also called sebaceous duct cyst onset most often near puberty.
Steatocystoma multiplex is an inherited disease but cases can also occur where there is no family history of the. A 32yearold man had multiple asymptomatic, yellowish to normal skincolored, moderately firm papules that were disseminated on the forehead, temple, and periauricular region. But some cases of steatocystoma multiplex seen on face and scalp. This suggests the disease may have a multifactorial etiology. Pathology of steatocystoma multiplex dr sampurna roy md. Steatocystoma multiplex is a rare familial hamartomatous malformation that is characterized by the presence of multiple intradermal cysts, and can result in abnormal breast examinations. Diagnosis is mainly clinical, but histopathology is characteristic and aids to confirmation of diagnosis when uncertain. Steatocystoma simplex commonly occurs in the skin of the forehead, nose, scalp, neck, axillae, chest, upper limbs, back, or legs 26. Steatocystoma simplex ss is a benign dermal cyst that is believed to originate from the. Similar appearance to compact keratin hyperkeratosis.
Aug 02, 2016 steatocystoma multiplex is a condition characterized by numerous skin cysts that tend to develop during puberty. Mar 12, 2019 first described by jamieson in 1873, and coined by pringle in 1899, steatocystoma multiplex sm is an uncommon disorder of the pilosebaceous unit characterized by the development of numerous sebumcontaining dermal cysts. We are reporting this case of steatocystoma simplex for its uncommon location in the penile foreskin, and its occurrence in a wapishana man. Steatocystoma simplex is the sporadic solitary tumor counterpart to sm and has no hereditary tendency.
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